Concentration dependent cartilage boundary lubricating ability of proteoglycan 4 monomers and multimers

Cartilage Boundary Lubricating Ability of Aldehyde Modified PRG4

INTRODUCTION: Proteoglycan 4 (PRG4) proteins, also known as lubricin and superficial zone protein, are encoded for by the PRG4 gene and are synthesized by cells that line joint surfaces. PRG4 is present in synovial fluid and at the surface of articular cartilage where it functions as a critical boundary lubricant necessary for joint health. A recent study, motivated by diminished PRG4 levels as...

The Effect of Molecular Weight on Hyaluronan’s Cartilage Lubricating Ability – Alone and in Combination with Proteoglycan

INTRODUCTION: Hyaluronan (HA), a primary constituent of synovial fluid (SF), is an important contributor to the boundary lubrication of articular cartilage. Indeed, high molecular weight (MW) HA, ~800 kDa, has been shown to function effectively as a cartilage boundary lubricant in a dose dependant manner, and act synergistically with Proteoglycan 4 (PRG4, a mucin-like glycoprotein also found in...

Synthesis of Proteoglycan 4 (PRG4) Disulfide-Bonded Multimers by Chondrocytes in Cartilage Explants

Alvarez, M C; Kooyman, J; +Schmidt, T A +University of Calgary, Calgary, AB, Canada [email protected] INTRODUCTION: Proteoglycan 4 (PRG4) is a mucin-like glycoprotein, also known as lubricin and superficial zone protein, that is synthesized by cells that line joint surfaces and is present both in synovial fluid and at the surface of articular cartilage. Chondrocyte synthesis and secretion of...

Polyelectrolyte properties of proteoglycan monomers

Boundary Lubrication and Boundary Lubricating Films

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